Synthetic peptides having hydroxyapatite binding ability can induce calcium phosphate (CaP) mineralization in simulated body fluids. The peptides freely dispersed in the solution induce formation of peptide-CaP hybrids having sheet-like morphologies, whereas immobilized on solid substrates they induce hydroxyapatite deposition on the substrate surfaces. The results clearly show that distribution of the peptides affects their mineralization properties.