Spray combustion is widely used in power, transportation, chemical and metallurgical, iron and steel making, aeronautical and astronautical engineering. In recent years, large-eddy simulation (LES) becomes more and more attractive, because it can give the instantaneous flow and flame structures, and may give more accurate statistical results than the Reynolds averaged Navier-Stokes (RANS) modeling. In this paper, the present status of the studies on LES of spray combustion is reviewed, and the future research needs are discussed.