This paper describes the most important articles that have been published on amino acid analysis using CE during the period from June 2009 to May 2011 and follows the format of the previous articles of Smith (Electrophoresis 1999, 20, 30783083), Prata et al. (Electrophoresis 2001, 22, 41294138) and Poinsot et al. (Electrophoresis 2003, 24, 40474062; Electrophoresis 2006, 27, 176194; Electrophoresis 2008, 29, 207223; Electrophoresis 2010, 31, 105121). We present new developments in amino acid analysis with CE, which are reported describing the use of lasers or light emitting diodes for fluorescence detection, conductimetry electrochemiluminescence detectors, mass spectrometry applications, and lab-on-a-chip applications using CE. In addition, we describe articles concerning clinical studies and neurochemical applications of these techniques.