Based on the entransy dissipation theory, the multi-parameter optimization design of recuperator is conducted in an Isopropanol-Acetone-Hydrogen (IAN) chemical heat pump system. The performance of the heat pump system can be improved significantly through the multi-parameter optimization, when the main operation parameters of chemical heat pump remain unchanged. When the main operation parameters of chemical heat pump and the heat transfer area of recuperator remain unchanged, the heat transfer rate of recuperator, the high-temperature heat released from the exothermic reactor, and the coefficient of performance (COP) and exergy efficiency of IAH heat pump system greatly increase while the compressor power decreases remarkably as entransy dissipation number decreases. This is done only by optimizing the combination of design parameters of recuperator taking entransy dissipation number as the objective function under certain constraint conditions, and the cost is no more than the low-temperature waste heat having no practical value. (C) 2012 Elsevier Ltd. All rights reserved.