This article reports an experimental investigation on the heat transfer, friction factor, and thermal enhancement factor of a tube equipped with vertical wing-cut twisted tapes, horizontal wing-cut twisted tapes, and plain twisted tapes with twist ratios of y = 2.0, 4.4, and 6.0. The obtained results reveal that the heat transfer rate, friction factor, and thermal enhancement factor in the tube equipped with horizontal wing-cut twisted tapes are significantly higher than those in the tube fitted with vertical wing-cut twisted tapes, plain twisted tapes, and a plain tube. An empirical correlation is subsequently derived from the experimental results.