The acrylic anion exchange resin of the quaternary ammonium and tertiary amine functionalities (Amberlite IRA 478RF) was tested as the effective sorbent for the removal of anionic dyes of increasing molecular size. The sorption of Acid Orange 7 (AO7), Reactive Black 5 (RB5), and Direct Blue 71 (DB71) was investigated by the batch and column methods. Modeling of kinetic results showed that the sorption of DB71 dye was best described by the pseudo first-order Lagergren equation. The pseudo second-order kinetics was found to be closer to the experimental data in the systems containing 200 mg/L AO7 or RB5. The Langmuir monolayer capacities were found to be 1279.2, 150.5, and 41.8 mg/g for AO7, RB5, and DB71, respectively. The influence of electrolytes such as Na2SO4, Na2CO3, and NaCl on the anion exchanger loading was also investigated. Methanol addition to the 1 M HCl, 1 M NaOH, and 1 M KSCN solutions improved dye desorption. Purification of the acid and direct wastewaters by means of Amberlite IRA 478RF was effective; 97% and 69.5% reduction of color was obtained, respectively.