The flotation process may be considered an interactive system consisting of many chemical, operational, and equipment variables. Changing any one of these variables causes an overall system response change. This study examines the effects of simultaneously changing the operating variables of: (1) frother concentration and air flow rate, and (2) frother concentration and collector concentration. It is part of a comprehensive study to look at how changes in several of the major variables may be used to produce interactions which will allow the rougher flotation process to be optimized. Ultimate recovery, flotation rate, concentrate grade and froth qualities are used as the major evaluative criteria.