In this work the fundamental problem of peristalsis with heat and mass transfer is investigated in the presence of a chemical reaction. An incompressible viscous fluid is considered in a channel with compliant walls. Mathematical modeling is based upon the laws of mass, linear momentum, energy and concentration. Analysis is presented not only for long wavelength and low Reynolds number but also for small Grashof number. The solutions are carried out for the stream function, temperature, concentration field and heat transfer coefficient. The results of various interesting parameters are plotted and discussed. (C) 2012 Elsevier Ltd. All rights reserved.