Twisted oval tube heat exchanger is a type of heat exchanger aims at decreasing the pressure drop of the shell side. In the present study, heat transfer and pressure drop performances of twisted oval tube have been studied experimentally and numerically. The experimental study of the twisted oval tube shows that heat transfer process can be enhanced but also with an increasing of pressure drop when compared with the smooth round tube. The effects of geometrical parameters on the performance of the twisted oval tube have been analyzed numerically. The result reveals that the heat transfer coefficient and friction factor both increase with the increasing of axis ratio a/b, while both decrease with the increasing of twist pitch length P. The influence of a/b and P on the overall performance of the twisted oval tubes are also studied. Aiming at obtaining the heat transfer enhancement mechanism of the twisted oval tube, secondary flow, total velocity and temperature distributions of flow section are given. From the analysis it can be concluded that the emergence of twist in the twisted oval tube results in secondary flow. It exists in the form of spiral flow when a/b is big, but in the form of up and down when a/b is small. It is this secondary flow that changes the total velocity and temperature distributions of the twisted oval tube when compared with a smooth oval tube with the same sectional geometric parameters. Then the synergy angle between velocity vector and temperature gradient is reduced and the heat transfer process is enhanced. (C) 2012 Elsevier Ltd. All rights reserved.