Four important plastics, namely polyvinyl chloride (PVC), polycarbonates (PC), poly acetal (POM) and polyphenylene ether (PPE) were successfully separated from their synthetic mixtures using common wetting agents like sodium ligninsulfonate, tannic acid, Aerosol OT and saponin. The efficient flotation separation amongst these naturally hydrophobic polymers could be attributed to the selective reduction in hydrophobicity (measured as the drop in contact angle) as a consequence of surfactant adsorption. The relative order of floatability measured with the help of column flotation experiments in the presence of various depressants selected for this study was found to be PPE > POM > PC > PVC, a trend consistent with the critical surface tension values determined for these solids except PPE. A flowsheet was developed on the basis of flotation results. It was possible to accomplish almost a perfect separation using the proposed flowsheet involving heavy media separation followed by flotation in two stages.