Optimization of combined cooling, heating, and power (CCHP) systems operation commonly focuses only on energy cost. Different algorithms have been developed to attain optimal utilization of CCHP units by minimizing the energy cost in CCHP systems operation. However, other outcomes resulting from CCHP operation such as primary energy consumption and emission of pollutants should also be considered during CCHP systems evaluation as one would expect these Outcomes can be subject to regulation. This paper presents an optimization of the operation of CCHP systems for different climate conditions based on operational cost, primary energy consumption (PEC), and carbon dioxide emissions (CDE) using an optimal energy dispatch algorithm. The results for the selected cities demonstrate that in general there is not a common trend among the three optimization modes presented in this paper since optimizing one parameter may reduce or increase the other two parameters. The only cities that show reduction of PEC while also reducing the CDE are Columbus, MS: Minneapolis, MN; and Miami, FL. For these cities the operational cost always increases when compared to the reference case consisting of using a vapor/compression cycle for cooling and natural gas for heating. On the other hand, for San Francisco and Boston, CCHP systems increase the CDE. In general, if CCHP systems increase the cost of operation, as long as energy savings and reduction of emissions are guaranteed, the implementation of these systems should be considered. (C) 2009 Elsevier Ltd. All rights reserved.