The present work is concerned with the interaction between large particles and gas phase turbulence. Gas turbulence modulation in these systems is considered to be dominated by a generation mechanism which arises due to the presence of wakes behind particles. Following a recent proposal, a closure for gas turbulence modulation accounting for the effect of wakes is employed within the context of a mathematical model for particle-laden, turbulent flows. The model accounts for particle-particle and particle-wall interactions associated with larger particles based on concepts from gas kinetic theory. It is shown that due to the significant flattening of the mean gas velocity profile with the addition of particles, and the corresponding decrease in turbulent energy production, a generation mechanism must be present in order to produce gas velocity fluctuation predictions which are consistent with the experimental measurements, even in the case where the experimental results indicate a net suppression of gas phase turbulence in the presence of particles.