The Clinical Trials Directive 2004 - whose mantra is to ensure good clinical practice as well as patient safety - has been met with mixed reviews. Filtration and Separation manufacturers are, unsurprisingly, enthusiastic as regulation increases demand for their equipment. But those that work at the sharp end of smaller, less commercial trials are more circumspect in their assessment, as Filtration + Separation found out on a visit to a clinical biomanufacturing facility in Oxford, UK.