Chemistry tabulation has been widely used in the literature to introduce some of the major subtleties of detailed chemistry in turbulent flame simulations. In the case of combustion systems featuring numerous degrees of freedom - such as progress of reaction, equivalence ratio, pressure, enthalpy, dilution by burnt gases - the rapidly growing size of the lookup-table file becomes one of the factor limiting chemistry introduction in high performance computing, because the database needs to be loaded on every processor whose memory is limited. A multi-zone self-similar chemistry tabulation technique is proposed to overcome this limitation, in both the cool-flame and the high-temperature flame regimes. A formalism is first developed for seeking self-similar behavior in auto-ignition. The resulting tabulation strategy is limited to the storage of a few profiles, to which algebraic relations are added. In the case of auto-igniting mixture, it is shown that major species of n-heptane-air and methane-air combustion can be captured by a single-set of self-similar profiles, opening perspectives for chemistry tabulation of multi-component liquid fuels. (C) 2011 Elsevier Ltd. All rights reserved.