A mathematical model predicting the oscillating motion in an oscillating heat pipe is developed. The model considers the system multidegree oscillation of vapor bubbles and liquid plugs, including the effects of filling ratio, operating temperature, gravitational force, and temperature difference between the evaporator and condenser. The model shows that the average velocity of liquid slugs is determined by the temperature difference between the evaporator and condenser. As the turn number increases, the temperature difference for the system to start the oscillating motion decreases. Increasing the bubble number will make the system more unstable and the system can be easily started up. The existence of gravity at the bottom heating mode will make the system easily produce the oscillating motion and decrease the temperature difference as well. Results presented here will assist in optimizing the heat transfer performance and provide a better understanding of heat transfer mechanisms occurring in the oscillating heat pipe.