This paper describes an experimental setup for the investigation of two-phase heat transfer inside microchannels and reports local heat transfer coefficients measured during flow boiling of HFC-245fa in a 0.96-mm-diameter single circular channel. The test runs have been performed during vaporization at around 1.85 bar, corresponding to 31 degrees C saturation temperature. As a peculiar characteristic of the present technique, the heat transfer coefficient is not measured by imposing the heat flux; instead, the boiling process is governed by controlling the inlet temperature of the heating secondary fluid. In the data, mass velocity ranges between 200 and 400 kg m(-2) s(-1), with heat flux varying from 5 to 85 kW m(-2) and vapor quality from 0.05 up to 0.8. Since these data are not measured at uniform heat flux conditions, a proper analysis is performed to enlighten the influence of the different parameters and to compare the present data to those obtained when the heat flux is imposed. Besides, the test runs have been carried out in a double mode: by increasing the water-to-refrigerant temperature difference and by decreasing it. Finally, the experimental data are compared to models available in the literature for predicting the heat transfer coefficients inside microchannels.