| 초록 |
γ-Secretase inhibitors which prevent Notch activation are emerging as potent therapeutics for diverse inflammatory diseases. However, their indiscriminate distribution in the body causes serious side effects after systemic administration. In this study, hyaluronan nanoparticles (HA-NPs) bearing a γ-secretase inhibitor (DAPT) were prepared as potential therapeutics for rheumatoid arthritis. In vivo biodistribution of the DAPT-loaded HA-NPs (DNPs), labeled with near-infrared dye, were observed using a non-invasive optical imaging system after systemic administration to a collagen induced arthritis (CIA) mouse model. The results demonstrated that DNPs were effectively accumulated at the inflamed joint of the CIA mice. From the in vivo therapeutic efficacy tests, DNPs significantly attenuated the severity of RA induction compared to DAPT. These results suggest that DNPs have the potential as therapeutics for rheumatoid arthritis. |
