| 학회 |
한국고분자학회 |
| 학술대회 |
2012년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
37권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Dissolution Properties of Control Released Solid Dispersion of Carvedilol with HPMC and Eudragit RS |
| 초록 |
In this study, solid dispersion for carvedilol was prepared by using spray-drying method. Solid dispersions were formulated with carvedilol and Eudragit RS and hydroxypropylmethylcellulose (HPMC) to control the dissolution rates of carvedilol. Scanning electron microscope (SEM) was used to analyze surface of solid dispersion samples. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were used to analyze the crystallinity of solid dispersions. Fourier-transform infrared spectroscopy (FT-IR) was used to analyze the change in chemical structure of solid dispersions. The release behavior of solid dispersion analyzed at simulated gastric fluid (pH 1.2) in in vitro study. The dissolution rate of carvedilol was higher than active phamaceutical ingredient (API). In conclusion, we can control the dissolution rate by solid dispersion using biomedical polymers. This research was supported by WCU (R31-20029). |
| 저자 |
이소진, 강길선, 심정보, 김민정, 이소진, 강수지, 김형석
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| 소속 |
전북대 |
| 키워드 |
Carvedilol; Eudragit RS; HPMC; Solid dispersion; Spray dry
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| E-Mail |
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