| 학회 |
한국고분자학회 |
| 학술대회 |
2018년 가을 (10/10 ~ 10/12, 경주컨벤션센터) |
| 권호 |
43권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 II |
| 제목 |
Cellular behaviours and Bioactive molecules release from Hyaluronate-based Micro-patterned Gel |
| 초록 |
A pattern gel was designed using hyaluronate and 1,4-butanediol diglycidyl ether by the micro-molding method. The cellular behavior of osteoblast cells on the pattern gel in the presence and absence of DMOG and NaB was studied for its application in bone regeneration. The micro-pattering of gel was obvious from SEM analysis. The gel behavior of the cross-linked gel was examined by swelling study in distilled water at 37 °C. The HA-BDDGE gel releases DMOG in a sustained way for up to 7 days in water at 37 °C. The gel is biocompatible and the DMOG containing gel showed better cell migration ability on the surface than NaB. The pattern gel with NaB or DMOG induced cell clusters formation. The in vitro results designated that the pattern gel exposed angiogenic and osteogenic responses with good ALP activity and enhanced HIF-1α, and Runx2 levels. Hence, the HA-BDDGE gel could be employed in bone regeneration application. |
| 저자 |
Dipankar Das1, 강철2, Janarthanan Gopinathan1, 노인섭1
|
| 소속 |
1서울과학기술대, 2화공생명공학과 |
| 키워드 |
Biopolymer; Biomedical application
|
| E-Mail |
|
