| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Angiongenic Effects of Demineralized Bone Matrix in the Repair of Calvarial Bone Defects |
| 초록 |
This study investigated the influence of DBM on angiogenesis and osteogenesis in a calvarial defect model. DBM/PLGA scaffolds were manufactured by solvent casting/salt leaching method, and each scaffold contained 10, 20, 40, 80wt% DBM respectively. Bicortical holes were placed on calvaria of rats and then filled with scaffolds. Histologic analyses were carried out concerning number, cross-sectional area of vessels and area, density of regenerated bone. In all experimental groups, bone formation occurred in a typical centripetal direction and new vessel formation took place in front of the osteogenic regeneration front. The 20wt% DBM scaffold was superior its ability to regenerate new bone, induced more intensive angiogenesis and expressed a highly osteocalcin level. DBM not only attracts osteoblasts into the bony defect and stimulates their differentiation, but also leads to more intensive angiogenesis by means of angiogenic activation, which plays an important role of bone formation. |
| 저자 |
윤선중, 박기숙, 김순희, 하현정, 최방실, 고연경, 강길선, 이종문
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| 소속 |
전북대 |
| 키워드 |
Angiogenesis; Bone regeneration; Demineralized bone matrix;
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| E-Mail |
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