| 학회 |
한국화학공학회 |
| 학술대회 |
2010년 가을 (10/21 ~ 10/22, 대전컨벤션센터) |
| 권호 |
16권 2호, p.1589 |
| 발표분야 |
생물화공 |
| 제목 |
Preparation of alendronate and BMP-2 loaded calcium phosphate microspheres |
| 초록 |
This study describes the preparation and characterization of alendronate and BMP-2 loaded calcium phosphate ceramic microspheres. The formation of calcium phosphate microspheres were initiated by enzymatic decomposition of urea and accomplished by emulsification process(water-in-oil). The microspheres obtained were sintered at 500℃ to remove organic compounds remained which potencially causes toxicity. The microspheres with a mean size range of 290um were in a spherical shape. Scanning electron microscope (SEM) indicated pores on the surface of the microspheres with random size. Energy dispersive X-ray spectroscopy (EDAX) showed that the ratio of calcium to phosphate was more than 1.18 both before and after sintering. X-Ray diffraction (XRD) analysis demonstrated that crystalline hydroxyapatite (HAp) and amorphous CaP phases coexisted within the microspheres.Alendronate and BMP-2 were loaded into the CaP microspheres through the pores. In the releasing profile, both drugssustainedlyreleased in 1mM PBS buffer. The CaP microspheres loading the drugs did not cause cytotoxicity in cells. |
| 저자 |
고일환1, 이진형2, 최진섭3, 장정호2
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| 소속 |
1한국세라믹기술원 / 인하대, 2한국세라믹기술원, 3인하대 |
| 키워드 |
CaP microsphere; alendronate; BMP-2
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| E-Mail |
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| 원문파일 |
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