| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 가을 (11/08 ~ 11/10, 부산 벡스코(BEXCO)) |
| 권호 |
21권 2호 |
| 발표분야 |
(정밀화학) 의학 진단 화학 프로브 및 약물 개발 |
| 제목 |
High-throughput Synthesis of a Novel Drug-like Anti-cancer Heterocycles Library using Combinatorial Synthetic Technology |
| 초록 |
The fused 5 or 6-member heterocyclic compounds offer a high degree of structural diversity and have proven to be broadly useful as therapeutic agents. In this respect, various approaches for these privileged structures with drug-like properties have been developed on solid-phase strategies with druggable design concept. In this symposium, my presentation covers several examples of the finding process of drug-like anti-cancer heterocyclic lead compounds through a key solid supported intermediate based on combinatorial synthetic technology. Some 5 or 6-membered core skeletons showed good anti-cancer activities toward various cancer targets. And then, I will mention about their pharmacological activities of a quinoxaline lead compound toward a novel anti-cancer target for new drug discovery. |
| 저자 |
공영대 |
| 소속 |
동국대 |
| 키워드 |
Combinatorial synthesis; Solid-phase synthesis; Heterocycles; Lead compound; Anti-cancer agent
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| E-Mail |
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