| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Evaluation of biocompatibility of CMC/PEI gel for rat bone marrow mesenchymal stem cells. |
| 초록 |
We describe the manufacture and characterization of an in situforming gel using CMC. We performed the in vivo seeding of rBMSCs in an in situforming CMC gel scaffold. The PEI solution was added to CMC solution to yield the desired concentration (030 wt%) of PEI for CMC. The CMC solution containing 10 wt% PEI transformed to a gel at temperatures greater than 35 oC and was chosen for subcutaneous injection into rats. It became a gel in the subcutaneous dorsum of the rats and maintained its shape even after 28 days in vivo. The injected rBMSCs survived in the CMC gel for 28 days. Injection of CMC/PEI gel alone induced macrophage accumulation in the host tissue and at the edge of the gel, whereas injection of CMC/PEI gel containing rBMSCs was associated with less macrophage accumulation, indicating immunosuppression by the transplanted rBMSCs. This indicates that rBMSC-containing CMC gel scaffolds show good biocompatibility and guarantee adequate engraftment within the host tissue. |
| 저자 |
강꽃님, 김이슬, 강윤미, 김경해, 김다연, 민병현, 김재호, 김문석
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| 소속 |
아주대 |
| 키워드 |
in situforming gel; rBMSC; CMC
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| E-Mail |
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