| 초록 |
For enhanced osteogenic support of blood-contacting medical device, hemo-compatibility is a crucial factor to induce fast and stable osteointegration in vivo. Here, we identified pyridoxal 5'-phosphate (PLP) from a library of phosphonic acid-containing molecules as a surface coating material and elucidated its roles on improved osteointegration. The surface-coated PLP greatly promoted hemophilicity of the implant and induced binding of plasma proteins by Schiff-base linkage, resulting in enhanced osteoblast adhesion and growth. PLP also increased platelet adhesion while delaying their activation and consequent blood coagulation. This allowed for sufficient supply of plasma proteins and migration of osteoblasts, which enhanced integration of the implant to surrounding bone tissues. Therefore, PLP would be a potential surface coating material of medical implants for enhanced tissue integration. This study was supported by a grant (2016R1A5A1004694) from TRCP funded by the MSIP of Korea. |
