| 학회 |
한국화학공학회 |
| 학술대회 |
2019년 가을 (10/23 ~ 10/25, 대전컨벤션센터) |
| 권호 |
25권 2호, p.1196 |
| 발표분야 |
고분자 (Polymer) |
| 제목 |
Functionalized conducting polymer as an aptamer immobilizing substrate for alpha-synuclein sensor |
| 초록 |
Parkinson's disease (PD) is one of the most common neurodegenerative disorders of later life. Alpha-synuclein (α-Syn) has been found to be one of the principal components of the Lewy-body that is thought to be the pathologic hallmark of PD. A highly sensitive electrochemical impedance sensor for α-Syn monitoring was fabricated using an aptamer immobilized on functionalized conducting polymers substrates: aptamer linked with poly (thiophene-3-acetic acid) (PTAA) or poly(pyrrole-carboxylate) [PPy-COOH]. The conducting polymers were employed for providing high electrical conductivity and linking agents. The sensing performace was investigated in terms of sensitivity and detection range. The fabricated sensor exhibited extremely low detection limit at a nano molar level. The developed α-Syn sensor could be utilized for the early diagnosis of PD. |
| 저자 |
김수찬, 유가연, 강병진, 조미숙, 이영관
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| 소속 |
성균관대 |
| 키워드 |
고분자 |
| E-Mail |
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| 원문파일 |
초록 보기 |
