| 학회 |
한국고분자학회 |
| 학술대회 |
2013년 가을 (10/11 ~ 10/12, 창원컨벤션센터) |
| 권호 |
38권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Bioactive Microspheres as an Injectable Bulking Agent for the Treatment of Fecal Incontinence |
| 초록 |
Fecal incontinence caused by pre-anal surgery and childbirth complications is a socially disabling disorder that profoundly impacts on all aspects of quality of life. Although injectable bulking agents are considered as a minimally invasive treatment, its low efficacy to treat the fecal incontinence caused by the injection volume decrement still remained as a clinical challenge. In this study, we prepared growth factor (bFGF and NGF)-loaded polycaprolactone (PCL) microspheres as a bioactive injectable bulking agent which may promote the function of sphincter muscle around anus (by sustain release of growth factors) as well as maintain the injection volution, and thus improve the cure rate of fecal incontinence. The growth factor release profile and myogenesis of muscle-derived progenitor cells on the microspheres were investigated [This work was supported by a grant of the Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A120357)]. |
| 저자 |
김태호1, 강준구1, 김옥선2, 강성범2, 오세행3, 이진호1
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| 소속 |
1한남대, 2서울대분당병원 외과, 3단국대 |
| 키워드 |
Fecal incontinence; Bulking agent; bFGF; NGF; Microspheres
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| E-Mail |
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