| 초록 |
De novo protein design has been historically used to validate the principles governing the process of biomolecular folding and assembly. However, de novo design of proteins from physical principles may have an even greater impact when applied to recognizing and organizing nanostructures. I demonstrate that nano-bio hybrid structures can be engineered to assemble in a structurally-specific manner, and this presents a promising way of addressing limitations in nanoscale assembly. Protein chemistry based on computational design will be introduced to engineer a series of hybrid structures composed of nanomaterials and artificial proteins. In addition, general rules for designing peptides that recognize surface lattices and self-associate to achieve superstructure will be described. This novel methodology for the construction of nano-bio hybrid materials, as well as the unique structural motifs, suggest a promising role for biomedical applications such as brain imaging and protein drug. |
