| 초록 |
The nanoparticle used for drug delivery system should have the high free volume in the medium for freely moving the active materials of high molecular weight. Hydrogel-type, cross-linked water-soluble polymer is suitable for enhancing the free volume of particles. In addition, the hydrophobic groups should be attached on the water-soluble polymer to prepare the amphiphilic block which can be self-assembled to form micelles in a selective solvent that was a precipitant for one of the copolymer components and a good solvent for the other component. Hydrophilic group, chitosan has biocompatibility, biodegrability, antibacterial properties and remarkable affinity to proteins. In particular, the amino group, which is rare in polysaccharides, of chitosan has influenced on the pH-responsive behavior, because pH-sensitive hydrogels usually contain either acid or basic pendent groups in the network. |
