| 초록 |
In this study, a new kind of multi-hydroxy synthetic polymer and preparation of the crosslinked gels are proposed. Poly(N-2,3-dihydroxypropyl aspartamide) (PDHPA), a poly(amino acid) with peptide backbone having pendent 1,2-dihydroxy functional groups, is prepared from the precursor polymer, polysuccinimide, through aminolysis using 3-amino-1,2-propanediol. This polyaspartamide derivative has several valuable properties including biodegradability, high water solubility, excellent biocompatibility, strong adhesive, and low production cost. Due to its unique chemical structure, PDHPA provides a useful platform to combine with other materials and also to prepare its dynamically reversible and self-healing hydrogel. |
