| 초록 |
The preparation and application of composite hydrogels based on the synthesized multi-hydroxy polymer are presented. Poly(N-2,3-dihydroxypropyl aspartamide) (PDHPA) is a type of poly(amino acid) and is composed of a peptide backbone and pendent 1,2-dihydroxy functional groups. By utilizing boric acid (BA) as a crosslinker, a hydrogel having dynamically reversible crosslinks can be prepared. The PDHPA-BA hydrogel possesses beneficial features including self-healing and pH-triggered sol-gel transition. The PDHPA and its hydrogel are innately hydrolytic degradable and biocompatible owing to the polypeptide backbone. In addition, they exhibit strong adhesion toward diverse surfaces. The mechanical performance and adhesiveness of the hydrogel can be enhanced by combining inorganic nanoparticles and/or a second polymer network. Notably, enhanced mechanical performance improves the failure mode of the PDHPA-BA hydrogel from cohesive failure to adhesive failure. |
