| 학회 |
한국공업화학회 |
| 학술대회 |
2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
26권 1호 |
| 발표분야 |
포스터-생물공학 |
| 제목 |
Droplet-based linear concentration gradient formation for applying on biological assay |
| 초록 |
We present a novel microfluidic platform producing monodisperse dropletshaving linear concentration gradient profile in a single device. Our strategy isutilizing significant difference of flow resistance of two aqueous phases: 1) Weintegrated parallel flow-focusing channels to produce the droplets containingeight different concentrations. We also introduced delivery channel which distributesthe fluids evenly to each flow-focusing channel at the same time to ensure theformation of uniform droplets. 2) We adopted multi-height structure andcontrolled the channel width of two aqueous phase channels. The difference inchannel height makes the lower part to be the only factor generating the concentrationgradients. We verified the linearity of the gradient based on fluorescenceintensity of the droplets. We look forward to using ourplatform as a biological assay tool such as antimicrobial susceptibilitytesting. |
| 저자 |
김진경, 김재성, 이창수
|
| 소속 |
충남대 |
| 키워드 |
Microfluidic; Droplet; Concentration gradient
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| E-Mail |
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