| 초록 |
Ceramide, the major lipid in the stratum corneum (SC), is critical for skin barrier function. But ceramide has a strong tendency to crystallize, so it is essential for controlling the molecular behavior of ceramide to stabilize the complex formulation. Herein, we introduced a systematic study of detailed behaviors of molecules in the ceramide/fatty alcohol particle system, which surface was armored by hydrophobically modified cellulose nanofibrils (CNFs). For this, we compared the interaction, pattern, and degrees of crystallization depending on the content of ceramide/fatty alcohol. Moreover, we observed the driving forces of CNFs affect the stabilization of interface and crystallization between internal molecules. We expect that these findings play a critical role in enhancing skin barrier function by developed ceramide formulations. |
