| 초록 |
Invasive bioelectrode, as called acupuncture needle, originated within the auspices of Oriental medicine, and today is used as an alternative method for treating various diseases and symptoms. The physiological mechanisms of invasive bioelectrode appear to involve the release of endogenous opiates and neurotransmitters, with the signals mediating through electrical stimulation of the central nervous system. Earlier we reported a invasive porous bioelectrode with enhanced therapeutic properties, evaluated by electrophysiological and behavioral responses in Sprague-Dawley rats. Herein, we investigate molecular changes in colorectal cancer rats by acupuncture treatment using the invasive bioelectrodes. Treatment at acupoint HT7 is found most effective at reducing average tumor size, β-catenin expression levels, and the number of aberrant crypt foci in the colon endothelium. Invasive porous bioelectrode further enhances the therapeutic effects of acupuncture treatment in CRC rats. |
