| 초록 |
Invasive bioelectrodes are widely used as an effective treatment for several acute and chronic diseases. In this study, we modify the surface of these invasive porous bioelectrodes with Ag, Au, Pt nanoparticles. Noble metal sensitized invasive porous bioelectrodes show increased low threshold (LT) and wide dynamic range(WDR) neuronal activity than others. In particular, Pt-sensitized invasive porous bioelectrodes show the highest WDR neuronal activity only upon insertion. In addition, Ag-sensitized invasive porous bioelectrodes show improved electrochemical properties with higher LT and WDR neuronal activity when stimulated. In chronic alcoholism test, the Ag-sensitized invasive porous bioelectrodes show 20% higher open arms time. These results suggest these noble the developed bioelectrodes may offer improved therapeutic outcomes for the treatment of chronic alcoholism, and enhanced electrophysiological properties. This poster is review of RSC Advances (2020) 10, 43514 – 43522 paper. |
