| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Functionalized Polymer Micelles for Targeted Delivery of Anticancer Drug |
| 초록 |
In recent years, there has been great interests in the development of nanoscopic therapeutic systems to improve drug delivery to target cancer cells. For this purpose, we focused on the development of a ligand-mediated polymeric micelle. Amphiphilic block copolymers composed of poly(ethylene glycol) and poly(ε-caprolactone) were synthesized and then conjugated with anti-EGFR for active targeting to cancer cells such as colon, lung, prostate, and breast cancer cell. The micelle formation of the block polymers in aqueous phase was confirmed by DLS and TEM analysis. Flow cytometric studies and microscopic analysis were carried out to elucidate selective targeting capability of micelles. |
| 저자 |
노태호1, 박치영1, 국연희1, 오은택1, 윤혜원1, 임민주1, 김하나1, 윤미경1, 최은경2, 박헌주1, 김철희1
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| 소속 |
1인하대, 2울산대 |
| 키워드 |
micelle; doxorubicin
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| E-Mail |
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