| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 봄 (04/12 ~ 04/13, 서울대학교) |
| 권호 | 27권 1호, p.291 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | In Vitro and In Vivo Antitumor Activities of BCNU-loaded PLGA Wafer against L 1210 Mouse Leukemia |
| 초록 | The localized, controlled delivery of anticancer agents using biodegradable polymeric implant is an alternative to the systemic administration of chemotherapeutic agents for treating malignant brain tumors. 1,3-bis(2-chloroethyl)-1-nitrosourea(BCNU) is one of the chemotherapeutic agents used for brain tumors, however, it's short half-life and systemic toxicity. In this study, BCNU-loaded PLGA disks were prepared as a new formulation for the controlled release of BCNU and their antitumor activity was evaluated in vitro and in vivo. In anititumor acitivity in vitro, change of cell density by BCNU released from wafer was assayed by dye exclusion method. In antitumor activity in vivo, a solid tumor was induced by the s.c. injection of 0.1 ml of L 1210 cell suspension (5 X 104 cells per mouse) in the flanks of BDF1 mice. Treatment was initiated at day 7 after injection of cells. Small incision was made above the tumor and BCNU-loaded PLGA wafer was implanted next to the tumor. Antitumor activities of the groups treated with BCNU-loaded PLGA wafers were evaluated by tumor size reduction and median survival rate. Acknowledgment: This work was supported by KMOCIE |
| 저자 | 안태군1, 이진수2, 문대식3, 김종민*4, 강길선, 이정옥**, 성하수***, 이해방*** |
| 소속 | 1전북대, 2*전북대, 3**한국화학(연), 4***한국화학(연) |
| 키워드 | |
