| 학회 | 한국공업화학회 |
| 학술대회 | 2014년 가을 (11/12 ~ 11/14, 엑스코(대구)) |
| 권호 | 18권 2호 |
| 발표분야 | 정밀화학-포스터 |
| 제목 | The direct reductive amination of aldehydes using S-Benzyl isothiouronium iodide as a recoverable organocatalyst |
| 초록 | Amines are highly versatile building blocks in natural products, pharmaceuticals, and agrochemicals. Reductive amination is one of the most powerful used methods for accessing different kinds of amines, in particular, when the carbonyl component is reacted directly with the amine and reducing agent, avoiding isolation of the imine intermediate. Isothiouronium salts have been explored recently as a new class of hydrogen-bonding subunit as thiourea. Isothiouronium group has more advantages: it enhances the NH acidity compared to the corresponding thiourea. Herein, we will discuss the effect of S-benzyl isothiouronium salts as an activator in the reductive amination of aldehydes from the viewpoint of the reaction rate depending on the counter anion of these salts. |
| 저자 | 이하늬, 김택현 |
| 소속 | 전남대 |
| 키워드 | organocatalyst; Hantzsch ester |
