| 학회 |
한국고분자학회 |
| 학술대회 |
2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터) |
| 권호 |
44권 2호 |
| 발표분야 |
콜로이드 및 분자조립 부문위원회 I |
| 제목 |
Preparation of PLGA hollow nanoparticles for drug delivery applications |
| 초록 |
PLGA (poly lactic-co-glycolic acid)) is a copolymer which had been approved by Food and Drug Administration (FDA) as therapeutic material owing to its biodegradability and biocompatibility. In this study, we fabricate hollow nanoparticles using PLGA by double-emulsion solvent evaporation/diffusion method. First emulsion is formed by mixing the water phase and the oil phase which is containing PLGA. In the mixture, the water phase is diffused in the oil phase homogeneously. The mixed solution is dropped into the water phase again to prepare second emulsion. To make clear hollow nanoparticles, we found optimized condition and observed with SEM and Bio-TEM whether they were hollow. Since PLGA is one of biocompatible materials, it can be applied to biotechnology such as drug delivery systems by introducing the desired substance in the hollow of the obtained nanoparticles. |
| 저자 |
김언지, 이재빈, 남기범, 이승우, 박진규, 이동윤
|
| 소속 |
경북대 |
| 키워드 |
PLGA; biocompatibility; nanoparticle
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| E-Mail |
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