| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
나노바이오기술용 고분자(의료용 고분자 부문위원회) |
| 제목 |
Fabrication of Porous Biodegradable Polymeric Microspheres using Hydrogen Peroxide as a Novel Porogen |
| 초록 |
Hydrogen peroxide (H2O2), a strong oxidizing agent, is a colorless liquid that is decomposed into water and oxygen when heated over 80 °C. It also decomposes in the presence of numerous catalysts, e.g., most metals, acids, or oxidizable organic materials and catalase. In this study, porous poly(lactide-co-glycolide) (PLGA) microspheres were fabricated by emulsion-solvent evaporation method using H2O2 as a gas foaming agent. H2O2 was mixed in the polymer emulsion droplets to generate oxygen gas bubbles during the solvent evaporation. Catalase was used as a H2O2 decomposition catalyst. This method is simple and environment-friendly, eliminating the use of salts. Sterilizing effect is also expected. Various conditions were tested and the resultant porous microspheres were characterized. |
| 저자 |
배순언1, 손준식1, 박귀덕1, 신흥수2, 안광덕1, 한동근1
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| 소속 |
1한국과학기술(연), 2한양대 |
| 키워드 |
Microsphere; Hydrogen peroxide; PLGA; Catalase
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| E-Mail |
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