| 학회 | 한국화학공학회 |
| 학술대회 | 2017년 봄 (04/26 ~ 04/28, ICC 제주) |
| 권호 | 23권 1호, p.376 |
| 발표분야 | 분리기술 |
| 제목 | Habit Modifying and Design of Agglomerated Crystals of Ibuprofen using aqueous Anti-solvent Crystallization |
| 초록 | Anti-solvent process is a suitable process for crystallize the thermally-sensitive materials like explosives, polymers and pharmaceutical ingredients. In this research, particle properties and the external morphology of unprocessed pharmaceutical materials are controlled by anti-solvent crystallization process. Ibuprofen(IBU), a representative component of non-steroidal anti-inflammatory NSAIDs was chosen for this study. Acetone was used as organic solvent, distilled water for anti-solvent and TWEEN-80 was used as a surfactant to solve the Agglomeration phenomena. Crystallization was simulated under the variables of Temperature, Concentration, sonication treated. The particles were characterized by scanning electron microscope (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD) and were evaluated for agglomeration tendency, particle size, chemical modification. IBU particles obtained from anti-solvent process are significantly changed in shape, size and agglomeration. Also, able to figure out Habit modifying tendency and agglomerate exhibition in this study. |
| 저자 | 백승욱, 여상도, 이승주 |
| 소속 | 경북대 |
| 키워드 | 결정화 |
| 원문파일 | 초록 보기 |
