| 학회 |
한국공업화학회 |
| 학술대회 |
2018년 가을 (10/31 ~ 11/02, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
22권 2호 |
| 발표분야 |
생물공학_포스터 |
| 제목 |
The study on Formulation of Supersaturatable Self-microemulsifying Drug Delivery System containing silymarin |
| 초록 |
Carduus marianus extract(Silymarin) has been used mainly as a medicament for hapatobiliary diseases. The major component of silymarin is silybin. But its bioavailibility is low after oral administration due to its low aqueous solubility. The purpose of this study was to develop supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) for improving solubility and dissolution rate of silymarin. The selected formulation of S-SMEDDS was comprised of oil(5% Capryol 90), S/Cos(2:1, 95% Tween 80/Transcutol P) with 1% CMC and Solutol HS 15. The S-SMEDDS formed a microemulsion after dilution with 185nm average droplet size and exhibited uniform droplet size distribution. The dissolution rate silymarin from S-SMEDDS showed about 80% release for 15 min. Therefore, it may be concluded that the developed S-SMEDDS formulation can be used an alternatively drug delivery system of silymarin to improve its solubility and dissolution rate. |
| 저자 |
장현상, 김은서, 정예주, 김주현, 조영호, 이계원
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| 소속 |
건양대 |
| 키워드 |
S-SMEDDS; Dissoultion; Solubility; Carduus marianus extract(silymarin)
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| E-Mail |
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