| 학회 |
한국공업화학회 |
| 학술대회 |
2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 |
23권 2호 |
| 발표분야 |
포스터_생체재료 |
| 제목 |
Effect of a Fluorescent Dye Conjugated with a Cell Penetrating Peptide for Cancer Therapy |
| 초록 |
We experienced cancer therapy using conjugated CPPs with ZW800-1 leaded to instant cell death like necrosis. The coupling reaction of ZW800-1, to clinical protamine (Pro) was performed to synthesis the new type of agent .The reaction between clinical protamine (Pro) and an NHS ester of dye is a solution phase reaction with the complete modification of the protamine peptides which feature a single reactive amine at the N-terminal and single carboxyl group at the C-terminal . cell death studies by conjugation of a protamine with ZW800-1 shows that a new types of agent has more efficient cytotoxic activities than each material alone, causing rapid cell death. This study aimed to identify a new type of agent for cancer cell therapy and to assess the antitumor effects of the newly synthesized agent using the Protamine-conjugated ZW800-1 on a cancer cell line. |
| 저자 |
RAVEENDRAN ATHIRA, 서진희, 조훈성
|
| 소속 |
전남대 |
| 키워드 |
Bioconjugation; Protamine; Fluorescent Dye; Cancer therapy
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| E-Mail |
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