| 학회 | 한국공업화학회 |
| 학술대회 | 2019년 가을 (10/30 ~ 11/01, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 23권 2호 |
| 발표분야 | 포스터_생체재료 |
| 제목 | Improvement of photodynamic therapy by conjugation of a cell-penetrating peptide with Methylene Blue |
| 초록 | Photodynamic therapy (PDT) causes tissue destruction by visible light in the presence of a photosensitizer (Ps) and oxygen, which promises alternative therapy that could be used an adjunct to chemotherapy and surgery for oncology. Methylene blue dye alone permeates into the cell and distributes through the cytoplasm, Protamine is one of the cell-penetrating peptides (CPPs), which has high arginine peptide with membrane translocating and nuclear localizing properties. So it makes localized to a specific spot of the cell by endocytosis and the localized conjugates enhances the generation of ROS enough to induce cell damages rapidly. In this study, we introduce the new type of PS and explore the effectiveness of PDT using MB-Pro in human colon cell lines, the new types of MB-Pro show more efficient photodynamic activities than MB alone, causing rapid and effective cell death. |
| 저자 | 서진희, Raveendran Athira, 조훈성 |
| 소속 | 전남대 |
| 키워드 | Photodynamic therapy; Bioconjugation; Protamine; Fluorescent dye; Methylene blue |
