| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 봄 (04/12 ~ 04/13, 제주 ICC) |
| 권호 |
32권 1호 |
| 발표분야 |
기능성 고분자 캡슐 공정 및 소재 |
| 제목 |
Preparation of Multiple coated pellet using Venlafaxine HCl |
| 초록 |
Venlafaxine is a phenethylamine antidepressant which inhibits both serotonin an dnorepinephrine reuptake and is structurally unrelated to the selective serotonin reuptake inhibitors (SSRLs). The objective of in this study was to confirm the release of velafaxine HCl and the storage stability. Multiple coated granules were prepared by fluidized bed coating method and consist of drug layer and membrane layer. The drug release from coated granules with multi layer was affected by the nature of coating agent, the percentage of coating level and the type of polymer in coating layer. HPMC and Eudragit RS, NE 30D was used for the controlling drug release rate and dibutyl sebacate was used for plasticizer. This designed oral delivery system is easy to manufacture, and drug releases behavior is highly reproducible and offers advantages over the existing commercial product. |
| 저자 |
박지선1, 서희1, 성하수1, 육순홍1, 황성주2, 조선행1
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| 소속 |
1한국화학(연), 2충남대 |
| 키워드 |
Venlafaxine HCl; multiple coated pellet; HPMC; Eudragit
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| E-Mail |
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