| 초록 |
Poly(N-vinyl-pyrrolidinone) (PNVP) has been used successfully as a basic material for the biomedical and pharmaceutical application such as drug delivery system and tissue engineering. The addition of poly(ethylene glycol) (PEG) to the PNVP hydrogel composition could provide various effects. In this study, PNVP based hydrogels modified by a PEG graft were prepared by the crosslinking polymerization of PNVP in the presence of PEG macromer with different amount and chain length. We investigated the effect of PEG graft into PNVP hydrogel, looking at the swelling property and morphology of the hydrogel which can affect of transport of bioactive molecules. The degree of swelling of the modified PNVP gels could be controlled and the resulting gels possessed a porous network structure with pore sizes ranging from submicron to tens of microns. |
