| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Characterization and Release Behavior of Zaltoprofen Tablet with the Additives. |
| 초록 |
Zaltoprofen is a propionic acid derivative of non-steroidal anti-inflammatory drugs (NSAIDs) and has been widely used in the treatment of arthritic conditions. Zaltoprofen has low water solubility and low bioavailability, therefore great efforts have been devoted to enhance the extent of drug adsorption. Zaltoprofen was formulated into a tablet to enhance the bioavailability and achieve sustained-release using additives such as carboxymethylcellulose (CMC), hydroxypropylmethylcellulose (HPMC). Fourier transfer-infrared and differential scanning calorimeter were employed to study the structure and crystallization of zaltoprofen in the tablet with various contents of additives. Additives had interactions with zaltoprofen and inhibited the crystallization of zaltoprofen. Tablets containing low viscosity HPMC showed a higher release than those containing high viscosity HPMC. As the amount of CMC increased zaltoprofen release increased. This research was supported by WCU(R31-20029). |
| 저자 |
박현진, 홍동현, 김혜린, 송재은, 홍민성, 송이슬, 서한솔, 유일수, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
zaltoprofen; dissolution rate; HPMC; CMC
|
| E-Mail |
|
