| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Improved transdermal permeation of FITC-BSA through the skin treated with micro-needles system. |
| 초록 |
To penetrate large molecules such as vaccine and protein drug(FITC-BSA) through skin treated with microneedle. FITC was dissolved in PBS and BSA was dissolved in DMSO. Two solutions were mixed at 4℃ and were stirred for 24h in the darkroom. Skin kept in 0.9% NaCl solution at 30min and treated with microneedle. The volume of 4mL PBS was added in Fransz-diffusion cell, and PBS 2mL was collected with time. It was analyzed fluorescent spectroscopy. The group of using 4R showed the highter rate than non treated and 2R types through the skin. We confirmed that permeation rate of BSA was increased with the treatment by microneedle and was increased by the increasing frequency of treatment. this research was supported WCU(R31-20029) |
| 저자 |
홍동현, 박현진, 김혜린, 송재은, 유동혁, 조한수, 송병주, 이동원, 강길선
|
| 소속 |
전북대 |
| 키워드 |
transdermal; micro-needles FITC; BSA
|
| E-Mail |
|
