| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
PLGA Microspheres Incorporated with TGF-β1/Chondroitin Sulfate Ionic Complex for Cartilage Tissue Engineering |
| 초록 |
Transforming growth factor-β (TGF-β) is a cytokine, which has an autocrine and paracrine action in the testis. It also displays potent immunoregulatory and anti-inflammatory activities. TGF-β1 with an isoelectric point (IEP) of 9.5 is an isoform of TGF-β that plays an important role in the growth and differentiation of articular cartilage. Chondroitin sulfate (CS) is a member of the glycosaminoglycal (GAG), an acidic mucopolysaccharide found in cartilage, skin, corneas, and umbilical cords. TGF-β1 is positively charged and forms a polyionic complex with negatively charged acidic CS (IEP of 5.0) at pH 7.4. In this study, the ionic complex of TGF-β1/CS was formed with different fractions of CS and TGF-β1. Poly(lactide-co-glycolide) (PLGA) microspheres incorporated with TGF-β1/CS ionic complex were fabricated by emulsion-solvent evaporation method. Various conditions were tested and the resultant PLGA microspheres with the ionic complex were characterized. |
| 저자 |
손준식, 조경진, 정홍희, 배순언, 신홍섭, 박귀덕, 한동근
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| 소속 |
한국과학기술(연) |
| 키워드 |
microsphere; ionic complex; PLGA; TGF-β1; cartilage
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| E-Mail |
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