| 학회 |
한국고분자학회 |
| 학술대회 |
2007년 가을 (10/11 ~ 10/12, 일산킨텍스) |
| 권호 |
32권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Evaluation of Biocompatible Zwitterionic PEG Grafted on Chemisorbed Nitinol-Au surface |
| 초록 |
Blood-compatible biomaterials have been of importance for a variety of medical applications. In this study, we have tested a Nitinol-Au whose surface was grafted with zwitterionic PEG, with the aim of development of peripheral arterial stent. Poly(ethylene glycol) (PEG) is blood-compatible and sulfobetaine (-N+-SO3-), a well-known class of zwitterionic polymer is biocompatible as well. After gold-coated Nitinol (Nitinol-Au) was chemisorbed by L-cysteine, cysteamine, and 3-mercaptopropionic acid (MPA), the zwitterionic PEG (PEG-N+-SO3-) was grafted onto the chemisorbed Nitinol-Au through the thiol group (-SH). The modified Nitinol-Au surfaces were characterized by electron spectroscopy for chemical analysis (ESCA), attenuated total reflectance-Fourier transform infrared (ATR-FTIR), and water contact angle measurement. The blood compatibility between surface-modified Nitinol-Au and blood components was also evaluated using plasma protein adsorption and platelet adhesion tests. |
| 저자 |
신홍섭1, 손준식1, 박귀덕1, 문명운1, 이광렬1, 김재진1, 김지흥2, 한동근1
|
| 소속 |
1한국과학기술(연), 2성균관대 |
| 키워드 |
Stent; Nitinol-Au; Zwitterionic PEG; Chemisorption; Surface modification; Blood compatibility
|
| E-Mail |
|
