| 학회 |
한국고분자학회 |
| 학술대회 |
2006년 봄 (04/06 ~ 04/07, 일산킨텍스) |
| 권호 |
31권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Self-assembly of amphiphilic copolymers as skin permeation enhancing carriers |
| 초록 |
Topical drug delivery system is one of the most interesting research fields in pharmaceutical and cosmetic industry. Many researchers have tried to increase skin permeation of active materials mainly by reducing their size. The purpose of this study is, however, to figure out other factors to have an effect on skin permeation and to optimize their condition. Here, novel nanoparticles based on poly(butylmethacrylate-co-[2-(methacryloyloxy)ethyl]trimethylammonium chloride) [poly(BMA-co-METAC)] are introduced for non-invasive drug delivery. These new carriers can transport biological active agents through the intact skin. This capability comes from not only deformability, but also surface charge of the carriers. In order to prove the main effects of deformability and surface charge, poly(butylmethacrylate), poly(methylmethacrylate) and its copolymer with METAC are used. These nanoparticles are applied onto the guinea pig skin in the Franz diffusion cell to verify our investigation. |
| 저자 |
김준오1, 심종원1, 류주희1, 김용진1, 장이섭1, 차국헌2
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| 소속 |
1(주)태평양/기술(연), 2서울대 |
| 키워드 |
피부흡수; 양친매성 공중합체; skin permeation; amphiphilic copolymer
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| E-Mail |
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